Helicobacter pylori
Conditions
Interventions
Keverprazan-minocycline dual therapy group :Keverprazan+minocycline
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients aged 18–70 years, regardless of gender; 2. Patients with H. pylori infection diagnosed by ¹³C/¹4C urea breath test (UBT) or rapid urease test (RUT); 3. No previous history of H. pylori eradication therapy; 4. Provision of informed consent and voluntary participation in the study.
Exclusion criteria
Exclusion criteria: 1. Individuals who were allergic to the study medication; 2. Use of antibiotics, bismuth agents, probiotics, or other such drugs within the past 4 weeks; or use of potassium-competitive acid blockers (P-CABs), proton pump inhibitors (PPIs), or H2-receptor antagonists within the past 2 weeks; 3. A history of failed H. pylori eradication therapy; 4. Current pregnancy, lactation, or pregnancy planning; 5.Patients with concomitant gastrointestinal malignancy, or a history of esophageal or gastric surgery; 6. Patients complicated by severe heart, liver, lung, or kidney diseases, as well as those with immunocompromise; 7. Patients unable to cooperate with the study due to alcoholism, substance abuse, severe mental illness, or other relevant conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events;Compliance; | — |
Countries
China
Contacts
Public ContactBengang Zhou
Northern Jiangsu People's Hospital
Outcome results
None listed