Nasopharyngeal carcinoma
Conditions
Interventions
Review training cohort:None
Sponsors
The First Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age greater than 18 years old; 2.Patients with histopathologically confirmed non-distant metastatic ( M0 ) nasopharyngeal squamous cell carcinoma ( refer to AJCC 8th edition staging ); 3.Patients were planned to receive radical radiotherapy or radiotherapy combined with systemic therapy ( chemotherapy, targeted therapy, immunotherapy ); 4.ECOG score 0-1; 5.There were no contraindications to chemotherapy, targeted therapy, immunotherapy and radiotherapy.
Exclusion criteria
Exclusion criteria: 1.Previously or simultaneously suffering from other uncured malignant tumors; 2.Have any active autoimmune diseases or have a history of autoimmune diseases ( such as interstitial pneumonia, uveitis, enteritis, hepatitis, hypophysitis, vasculitis, myocarditis, nephritis, hyperthyroidism, hypothyroidism ( hormone replacement therapy can be included after normal ) ) ; patients with vitiligo or childhood asthma who have achieved complete remission and do not require any intervention after adulthood can be included. Asthmatic patients who require medical intervention with bronchodilators cannot be included. 3.Patients with uncontrolled cardiovascular disease : myocardial ischemia or myocardial infarction above grade II, poorly controlled arrhythmia ( including QTc interval >= 470 ms ) ; according to NYHA standard, grade III ~ IV cardiac insufficiency, or left ventricular ejection fraction ( LVEF ) < 50 % by echocardiography ; myocardial infarction occurred within 1 year. 4.The doctor 's diagnosis is not suitable for radiotherapy; 5.Within 4 weeks before the first radiotherapy ( the subjects who have entered the follow-up period are calculated based on the time of the last use of experimental drugs or instruments ) or are participating in other clinical studies; 6.Pregnant or lactating women; 7.The researchers determined that the subjects had other factors that might cause them to be forced to terminate the study, such as the need for combined treatment for other serious diseases ( including mental illness ), serious abnormalities in laboratory test values, family or social factors that may affect the safety of the subjects or the collection of test data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy of tumor deformation prediction model; | — |
Secondary
| Measure | Time frame |
|---|---|
| Performance of dose distribution reconstruction model;Treatment outcome;Proteomics and Biological Interpretability;The performance of tumor deformation prediction model; | — |
Countries
China
Contacts
Public ContactQiao Qiao
The First Hospital of China Medical University
Outcome results
None listed