Elderly knee arthroplasty
Conditions
Interventions
Oxycodone Group:At 2 minutes before skin incision, patients in the Oxycodone Group received an intravenous injection of oxycodone at a dose of 0.02 mg/kg.
Control Group:At 2 minutes before skin incision, patients in the Control Group received an intravenous injection of sufentanil at a dose of 0.1 µg/kg.
Sponsors
Special Scientific Research Fund of Wu Jieping Medical Foundation
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years old, American Society of Anesthesiologists (ASA) physical status ?~?, body mass index (BMI) 18.5~30 \mathrm{kg/m^2}; 2. Elderly patients scheduled for elective knee arthroplasty; 3. Informed consent obtained from patients and their family members.
Exclusion criteria
Exclusion criteria: 1. Preoperative pulse oxygen saturation (SpO2) < 90% or arterial partial pressure of oxygen (PaO2) <= 60 mmHg; 2. Patients with allergy to opioids, a history of opioid addiction, or participation in other clinical studies; 3. Patients with a history of epilepsy or depression; 4. Patients with severe organ dysfunction or failure (e.g., liver failure, renal failure, respiratory failure, etc.); 5. Patients with severe infection; 6. Patients with severe mental system diseases who cannot cooperate with the study or are taking antipsychotic drugs; 7. Patients who are deemed ineligible for participation in this study by the researchers for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale (VAS);Number of PCA pump presses within 48h postoperatively;Rescue analgesia status within 48h postoperatively;Adverse reaction occurrence status within 48h postoperatively;Homocysteine (Hcy) concentration in peripheral venous blood;Mini-Mental State Examination (MMSE); | — |
Secondary
| Measure | Time frame |
|---|---|
| Stress response indicators;S100ß protein in peripheral venous blood;Neuron-Specific Enolase (NSE) in peripheral venous blood; | — |
Countries
China
Contacts
Public ContactLing Yunzhi
The First Affiliated Hospital of Bengbu Medical University
Outcome results
None listed