Congenital Heart Disease?
Conditions
Interventions
Sufentanil group :None
Oxycodone group:None
Sponsors
Shanghai Children's Medical Center
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Children undergoing elective congenital heart disease surgery under CPB from December 2022 to November 2025; 2. Children <=18 years old; 3. Oxycodone or sufentanil was prescribed in the induction protocol; 4. Children with complete perioperative records and inflammatory factor test results within 0-72 hours after surgery in the medical record system.
Exclusion criteria
Exclusion criteria: 1. Children with definite preoperative diagnosis of hepatic and renal insufficiency; 2. Children with definite infection, sepsis or autoimmune diseases before surgery; 3. Emergency surgery, non-CPB surgery or other non-cardiac major surgery at the same time; 4. Children who need to use other types of opioids for continuous analgesia during or after surgery for any reason, which may interfere with the evaluation of the effect of the study drugs; 5. Cases with serious missing clinical data that could not be effectively analyzed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin-1 Beta;Interleukin-2;Interleukin-4;Interleukin-5;Interleukin-6;Interleukin-8;Interleukin-10;Interleukin-12 p70;Interleukin-17;Interferon-alpha;Interferon-gamma;Tumor Necrosis Factor Alpha;Hospital Length of Stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of Mechanical Ventilation;Length of stay in the Cardiac Intensive Care Unit; | — |
Countries
China
Contacts
Public ContactJi Wei
Shanghai Children's Medical Center
Outcome results
None listed