Central sensitization related to chronic pain
Conditions
Interventions
HF-rTMS group:Healthy subjects were randomly assigned to receive the high - frequency repetitive transcranial magnetic stimulation (HF - rTMS) protocol. The coil was positioned over the left primary m
stimulus frequency, 10 Hz
pulses per train, 10
number of trains, 16
inter - train interval, 26 s
stimulus intensity, 80% of the resting motor threshold (RMT).
Sham group:Healthy subjects were randomly assigned to receive the sham protocol. During sham stimulation, the coil was positioned at a 90° angle to the scalp
the number of pulses per train was 10, the number of trains was 16, the inter-train interval was 26 s, and the stimulus intensity was set at 80% of the resting motor threshold (RMT).
Sponsors
Guangdong Provincial People’s Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 20 and <= 60 years, either sex. 2. Right-handed. 3. No history of chronic pain. 4. Has understood the study’s purpose and procedures, agreed to undergo evaluation, treatment and follow-up, and signed the informed-consent form.
Exclusion criteria
Exclusion criteria: 1. Known allergy to capsaicin; 2. History of skin disorders on the forearm; 3. History of neurological disease; 4. History of epileptic seizures; 5. Metallic implants in the head, neck, or chest; 6. Any other contraindication to TMS evaluation or treatment; 7. Use of analgesic or psychotropic medication within one month before study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CPM function score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analog Scale;fNIRS brain functional imaging ; | — |
Countries
China
Contacts
Public ContactXu Guangqing
Guangdong Provincial People’s Hospital
Outcome results
None listed