Exposure Keratopathy
Conditions
Interventions
Perfluorohexyloctane Eye Drops Arm:Following the establishment of satisfactory anesthesia, the study eye received instillation of the medication every two hours until the end of the surgery.
Transparent Dressing Eyelid Closure Arm:Following the establishment of satisfactory anesthesia, the control eye received transparent dressing eyelid closure until the end of the surgery.
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years, male or female. 2. Patients scheduled for supine general anesthesia surgery (non-ocular and non-head/neck surgery), with the surgical preparation area not involving the periorbital skin, and allowing for convenient administration of the medication during the procedure. 3. Patients voluntarily agree to participate in this study and are able to cooperate throughout the entire research process.
Exclusion criteria
Exclusion criteria: 1. Patients with acute ocular diseases (e.g., conjunctivitis, keratitis) or pre-existing lagophthalmos. 2. Patients using topical ophthalmic medications that will be continued during the perioperative period, such as anti-glaucoma agents or artificial tears. 3. Patients who have undergone ocular surgery within the past 3 months. 4. Long-term contact lens wearers, or patients with pre-existing severe ocular conditions that would interfere with ocular examinations. 5. Patients with severe Graft-versus-Host Disease (GVHD), Sjögren's syndrome, Stevens-Johnson syndrome, or similar conditions. 6. Pregnancy. 7. Patients unable to cooperate with the required examinations and follow-up visits. 8. Anticipated surgical duration >12 hours or expected intraoperative blood transfusion >2500 ml. 9. Any other condition deemed by the investigator to make the patient unsuitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dry Eye Symptom VAS Score;Tear Film Break-Up Time (TBUT);Corneal Fluorescein Staining Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Slit-Lamp Examination;Schirmer's test;Tear Fluid Biomarker;Conjunctival Hyperemia Score;Vision;Tear Meniscus Height (TMH);Meibomian Gland Area Score;Corneal clarity;Status of the eyelid skin; | — |
Countries
China
Contacts
Public ContactLi Li
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed