postoperative nausea and vomiting
Conditions
Interventions
Sufentanil Group:Administer 5 µg of sufentanil intravenously 30 minutes before the end, and use sufentanil PCIA (100 µg/100 ml) for postoperative analgesia.
Tegileridine Group:Inject 0.5 mg of Tegileridine intravenously 30 minutes before the end of surgery, and use Tegileridine PCIA (5 mg/100 ml) for postoperative analgesia.
Sponsors
International Peace Maternity and Child Health Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female patients aged 18 to 65 years (inclusive); 2. Classified as ASA I to II by the American Society of Anesthesiologists, with physical condition capable of tolerating surgery and anesthesia; 3. Planning to undergo elective gynecological laparoscopic surgery under general anesthesia; 4. Fully understand the study content, voluntarily participate, and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Individuals known to have a history of allergy to sufentanil, Tegileridine, or any components of their formulations; 2. Individuals who have used opioid or non-opioid analgesics long-term before surgery (routine use >1 week), or those with a history of drug abuse; 3. Female patients who are pregnant or breastfeeding; 4. Individuals with uncontrolled severe mental illness or cognitive dysfunction, who are unable to cooperate with pain and recovery quality assessments; 5. Individuals with conditions that may interfere with the assessment of postoperative nausea and vomiting (PONV), such as uncontrolled gastrointestinal diseases (gastric ulcer, pyloric obstruction, etc.), severe liver function abnormalities (e.g., acute hepatitis), or vestibular dysfunction; 6. Situations judged by the investigator as otherwise unsuitable for participation in this clinical study (e.g., critical illness, communication barriers); 7. Patients or their legal representatives who refuse to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of nausea and vomiting within 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of nausea, vomiting, and retching within 24 hours after surgery;Dosage of droperidol as rescue antiemetic after surgery;Numeric Pain Rating Scale (NPRS) scores ;Postoperative analgesia satisfaction;Dosage of oxycodone as rescue analgesic after surgery;15-item Quality of Recovery Score at 24 Hours Postoperatively and Its Change from Preoperative Baseline;Incidence of opioid-related adverse events;Time to first postoperative flatus; | — |
Countries
China
Contacts
Public ContactJianwei Wang
International Peace Maternity and Child Health Hospital
Outcome results
None listed