Adolescent MDD
Conditions
Interventions
Sham group:The current intensity is 2mA, with a duration of 1 minute (rising for 30 seconds and falling for 30 seconds) to simulate a real-life stimulation experience, lasting for 30 minutes.
Real group:The stimulation frequency is an envelope frequency of 10Hz, with a treatment duration of 10 days, a current intensity of 2mA, and a duration of 30 minutes.
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 12 and 18 years, regardless of gender. 2. Meet the MDD diagnostic criteria for DSM-V; 3. The score of HAMD-17>=17; 4. Right-handed; 5. Routine blood, electrocardiogram indicators are all normal; 6. After fully understanding the safety of transcranial electrical stimulation, I am willing to actively cooperate with the treatment and have both myself and my family sign informed consent; 7. The types of drugs have remained unchanged and the dosages have been stable in the past two weeks.
Exclusion criteria
Exclusion criteria: 1. Other physical therapies, such as electroconvulsive shock, transcranial magnetic stimulation, transcranial electrical stimulation, etc., were received within 3 months before enrollment; 2. Those with a history of severe physical illness and depression caused by other psychoactive substances and non-dependent substances; 3. Subjects who have metal or electronic devices implanted in their bodies, such as intracranial metal foreign bodies, cochlear implants, pacemakers and stents, etc; 4. There is a risk of epileptic seizures, with a history of craniocerebral diseases, head trauma, alcohol abuse, abnormal electroencephalograms, MRI evidence of abnormal brain structure, or a family history of epilepsy; 5. There has been a history of attempted suicide in the past two weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of 17-item Hamilton Depression Rating Scale (HAMD-17) scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMA, CDI,BSI, OSI and PSQI;Adverse Event;Multimodal neuroimaging features;Brain derived neurotrophic factor; | — |
Countries
China
Contacts
Public ContactXiaoli Liu
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed