Postoperative cognitive dysfunction
Conditions
Interventions
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective coronary artery bypass grafting (CABG); 2. No cognitive impairment on the Montreal Cognitive Assessment (MoCA) preoperatively: (1) Illiterate patients with score >= 17; (2) Patients with primary school education (education duration = 20; (3) Patients with junior high school or higher education with score >= 25; 3. ASA classification II–IV; 4. Voluntarily signed informed consent for surgery and study; 5. No previous history of cardiac surgery; 6. Not enrolled in any other clinical studies.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of central nervous system or psychiatric disorders; 2. Those taking antidepressants or sedatives long-term, or long-term heavy drinkers (weekly alcohol intake >= 350g); 3. Those who have participated in other clinical trials or are unable to cooperate with this study; 4. Visual or auditory impairments severely affecting neuropsychological assessment; 5. Patients with mental or neurological disorders who cannot cooperate with POCD assessment before or after surgery; 6. Patients with other cardiovascular diseases requiring concurrent surgery; 7. Patients with claustrophobia; 8. Patients unable to lie flat; 9. Patients who refuse to sign the informed consent form; 10. Patients undergoing emergency cardiac surgery; 11. Patients with a history of neurosurgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Receiver operating characteristic curve;Area under curve;Accuracy;Precision;Recall rate;F1 score;POCD Neuropsychological Assessment;MRI scan of the head; | — |
Countries
China
Contacts
Public ContactLiu Wenjun
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed