Irritable bowel syndromes
Conditions
Interventions
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for IBS: 1. Age 30-70 years; 2. Meeting the Rome IV diagnostic criteria: Recurrent abdominal pain for at least one day per week in the last three months, associated with two or more of the following features: (1)Pain related to defecation; (2) Change in frequency of stool associated with the onset of pain; (3) Change in form (appearance) of stool associated with the onset of pain. Inclusion Criteria for Acute Diarrhea: 1. Age between 30 and 70 years. 2. Passage of three or more unformed, yellow-brown stools within a 24-hour period, without pus or blood. 3. Duration of illness not exceeding two weeks; Inclusion Criteria for intestinal obstruction: 1. Age 30-70 years; 2. Diagnosis of intestinal obstruction confirmed by imaging (standing abdominal X-ray / CT). Inclusion Criteria for healthy volunteers: Age 30-70 years.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for IBS:Exclusion Criteria: 1. Patients with abdominal pain or diarrhea caused by other organic diseases; 2. Patients with diarrhea or constipation caused by other diseases; 3. History of abdominal surgery, except for appendectomy; 4. Presence of multiple peripheral vascular lesions; 5. Patients with severe concomitant diseases of the heart, liver, lungs, kidneys, blood system, endocrine system, nervous system, or autoimmune diseases; 6. Use of antibiotics or systemic corticosteroids within the past month; 7. Pregnant or lactating women; 8. Patients with severe psychiatric disorders, such as schizophrenia or bipolar disorder; 9. Inability to communicate normally; 10. Patients who have not provided informed consent; or any patient whom the investigator, based on medical judgment, deems unsuitable to participate in this study. This includes, but is not limited to, inability to comply with the study protocol, poor adherence, potential safety risks, or other factors that may compromise the integrity of the study data. Exclusion Criteria for Acute Diarrhea: 1. Special causative pathogens (e.g., cholera, dysentery, typhoid fever), anatomical defects, or congenital factors (e.g., malabsorption syndromes). 2. Concurrent severe dehydration, severe malnutrition or edema, and those with frequent vomiting who are unable to eat. 3. Patients with severe concomitant diseases of the heart, liver, lungs, kidneys, blood system, endocrine system, nervous system, or autoimmune diseases. 4. Pregnant or lactating women. 5. Patients with severe psychiatric disorders, such as schizophrenia or bipolar disorder. 6. Inability to communicate normally. 7. Patients who have not provided informed consent; or any patient whom the investigator, based on medical judgment, deems unsuitable to participate in this study. This includes, but is not limited to, inability to comply with the study protocol, poor adherence, potential safety risks, or other factors that may compromise the integrity of the study data. Exclusion Criteria for intestinal obstruction:1. Patients with complete intestinal obstruction requiring emergency surgery. 2. Patients with severe concomitant diseases of the heart, liver, lungs, kidneys, blood system, endocrine system, nervous system, or autoimmune diseases. 3. Pregnant or lactating women. 4. Patients with severe psychiatric disorders, such as schizophrenia or bipolar disorder. 5. Inability to communicate normally. 6. Patients who have not provided informed consent; or any patient whom the investigator, based on medical judgment, deems unsuitable to participate in this study. This includes, but is not limited to, inability to comply with the study protocol, poor adherence, potential safety risks, or other factors that may compromise the integrity of the study data. Exclusion Criteria for healthy volunteers:Exclusion Criteria: 1. History of chronic diseases. 2. Patients with severe concomitant diseases of the heart, liver, lungs, kidneys, blood system, endocrine system, nervous system, or autoimmune diseases. 3. Pregnant or lactating women. 4. Patients with severe psychiatric disorders, such as schizophrenia or bipolar disorder. 5. Inability to communicate normally. 6. Patients who have not provided informed consent; or any patient whom the investigator, based on medical judgment, deems unsuitable to participate in this study. This includes, but is not limited to, inability to comply with the study protocol, poor adherence, pote
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bowel sounds,Gastrointestinal Symptom Rating;Irritable Bowel Syndrome - Severity Scoring ;Bristol Stool Form ; | — |
Countries
China
Contacts
Public ContactYuxin Leng
Peking University Third Hospital
Outcome results
None listed