postoperative nausea and vomiting
Conditions
Interventions
Esketamine Group (Group E):Intravenous administration of low-dose esketamine and lidocaine
Sufentanil Group (Group S):Intravenous administration of sufentanil
Sponsors
Shenzhen Maternity & Child Healthcare Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female patients aged 18–65 years (inclusive); 2. BMI ranging from 18.5 to 28 kg/m²; 3. ASA physical status classification Grade I–II; 4. Scheduled for elective day-case hysteroscopic surgery; 5. Anticipated surgical duration <= 60 minutes.
Exclusion criteria
Exclusion criteria: 1. Allergy to esketamine, lidocaine, propofol or sufentanil; 2. Preoperative hemoglobin < 70 g/L; 3. History of mental illness; 4. Severe cardiovascular disease; 5. Hepatic or renal insufficiency; 6. History of epilepsy; 7. History of arrhythmia; 8. Administration of anti-anxiety, antidepressant or sedative-hypnotic drugs within the past month; 9. History of local anesthetic systemic toxicity (LAST) within recent 6 months; 10. Lactating individuals.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 15-item Quality of Recovery (QoR-15) score at 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate (HR), mean arterial pressure (MAP);Total dosage of remifentanil; | — |
Countries
China
Contacts
Public ContactYan Yuting
Shenzhen Maternity & Child Healthcare Hospital
Outcome results
None listed