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Clinical Efficacy and Neural Mechanism of Mirror Therapy on Upper Limb Function Rehabilitation after Stroke

Clinical Efficacy and Neural Mechanism of Mirror Therapy on Upper Limb Function Rehabilitation after Stroke

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600116634
Enrollment
Unknown
Registered
2026-01-13
Start date
2026-01-16
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke with unknown ischemia or hemorrhage

Interventions

The bilateral mirror therapy group (Part Three):The patient performed symmetrical movements with both hands. The movement of the healthy hand created visual feedback for the affected hand through mirr
The single-handed mirror therapy group (Part Three):Only the healthy hand moves in front of the mirror, while the affected hand is hidden behind the mirror and remains stationary.
The pseudo-mirror therapy group (Part Three):Based on the results of the first part of the study, the "most fake" pseudo-mirror treatment (transparent glass, opaque partition, or no mirror) was select
False Mirror Therapy 1 (Part One):Transparent glass was used instead of mirrors. The rest was the same as the real mirror therapy. All the research subjects, including 30 healthy individuals and 30 pa
False Mirror Therapy 2 (Part One):Opaque partition, the rest is the same as the real mirror therapy. All the research subjects, including 30 healthy individuals and 30 patients, were successively subj
False Mirror Therapy 3 (Part 1):Without a mirror, both hands perform the same action simultaneously. All the research subjects, including 30 healthy individuals and 30 patients, were successively subj

Sponsors

Wuhan Wuchang Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Healthy subjects 1. Male or female patients aged between 18 and 80 years old; 2. Right-handed (Edinburgh Handedness Inventory score >= 80%), without left-handedness or bilateral handedness history. Stroke patients 1.Male or female patients aged between 18 and 80 years old; 2. Within 1-6 months after onset; 3. Upper limb Fugl-Meyer score is 10-45 points, with basic grasping function retained (such as palm grasping, object release); 4.MMSE score >= 24 points, without severe cognitive impairment; 5. No mental illness, no neurological muscle disease, no severe aphasia or hearing comprehension impairment.

Exclusion criteria

Exclusion criteria: Healthy subjects 1. Exclude severe visual impairments (such as uncorrected severe myopia / hyperopia, visual field defects); 2.Special reasons preventing participation in the complete experiment. Stroke patients 1.Bilateral stroke or severe ataxia; 2. History of epilepsy induced by mirror vision; 3. Severe joint contractures (passive ROM limitation > 50%).

Design outcomes

Primary

MeasureTime frame
Fugl-Meyer Assessment for Upper Extremity;Changes in oxygenated hemoglobin concentration measured by functional near-infrared spectroscopy (fNIRS-?HbO);Simulator Sickness Questionnaire (SSQ);

Secondary

MeasureTime frame
Action Research Arm Test;Modified Barthel Index;Hand Function Subdomain of the Stroke Impact Scale (SIS);Visual Analog Scale;Mini-Mental State Examination;Likert Scale ;System Usability Scale (SUS) ;Functional Independence Measure;Changes in oxygenated hemoglobin concentration measured by functional near-infrared spectroscopy (fNIRS-?HbO);

Countries

China

Contacts

Public ContactYang Tangzhu

Wuhan Wuchang Hospital

tangzhuyang@qq.com+86 27 8811 0060

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026