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Comparison of Bupivacaine Liposome with Modified Cocktail Formula for Local Infiltration Anesthesia and Analgesia in Promoting Rapid Recovery after Hemorrhoid Surgery: A Prospective, Double-Blind, Randomized Controlled Clinical Study Protocol

Comparison of Bupivacaine Liposome with Modified Cocktail Formula for Local Infiltration Anesthesia and Analgesia in Promoting Rapid Recovery after Hemorrhoid Surgery: A Prospective, Double-Blind, Randomized Controlled Clinical Study Protocol

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600116630
Enrollment
Unknown
Registered
2026-01-13
Start date
2026-01-15
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mixed hemorrhoids

Interventions

Bupivacaine Liposome Group:266 mg of bupivacaine liposome injection in 20 ml is divided into 6 equal doses, with 3 ml administered per injection site, for a total of 18 ml.

Sponsors

Sichuan University, West China Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Patients suitable for hemorrhoid surgery. 2. The preoperative ASA classification was grade I to III; 3. Age: 15-75 years old Gender is not limited. 4.BMI is 18 to 28 kg/m^2; 5. Complete medical records; 6. Both the patient and their family members were aware of this study. The patient voluntarily participated in this experiment and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Allergic to the drugs used in this research, as well as local anesthetic drugs or opioids; 2. Suffering from severe heart diseases (unstable angina pectoris, myocardial infarction within the last 3 months, etc.), severe liver and kidney dysfunction, and coagulation dysfunction; 3. Receive analgesic drug treatment 24 hours before the operation; 4. Undergo various surgical operations; 5. Long-term history of opioid use or drug abuse.

Design outcomes

Primary

MeasureTime frame
Pain score;

Secondary

MeasureTime frame
Serum inflammatory marker levels;Assessment of early bowel function recovery;Recovery of sphincter function;QOR-15 questionnaire;Wound healing status;Complete postoperative pain resolution;Adverse reactions;

Countries

China

Contacts

Public ContactHanlin Gong

Sichuan University, West China Hospital

ncghl999@163.com+86 138 8091 2113

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026