Chronic kidney disease
Conditions
Interventions
Home-based remote ischemic preconditioning group:On top of conventional therapy, patients are instructed to perform remote ischemic preconditioning (RIPC) at home. The protocol consists of four daily
Control group:Receive only conventional pharmacological treatment and basic management, including dietary control and standard medication, without any EECP or RIPC interventions.
In-hospital enhanced external counterpulsation group:On top of conventional therapy, in-hospital enhanced external counterpulsation (EECP) is added. The protocol is as follows: one session per day, la
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Patients who meet the diagnostic criteria for CKD stage 1-5 and whose condition is stable. 2.Age: 20-50 years old. 3.Patients who are conscious and able to cooperate with treatment. 4.Patients and their families who have given their consent to participate in the study and have signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients who have been taking folic acid, vitamin B12, or other medications that affect Hcy serum levels for the past 3 months. 2.Patients with combined malignant tumors, severe malnutrition, acute and chronic infectious diseases, active liver disease, immune system disorders, malignant or refractory hypertension, mental illnesses, and those who are uncooperative. 3.Pregnant and breastfeeding women. 4.Patients with contraindications to external counterpulsation and remote ischemic preconditioning therapy: limb venous thrombosis, abdominal aortic aneurysm, aortic dissection, heart rate >= 140 beats per minute, aortic valve regurgitation, individuals with a tendency toward systemic or localized bleeding (thrombocytopenia, abnormal coagulation function, etc.), active cerebral hemorrhage, ascites, pulmonary embolism, and moderate to severe pulmonary heart disease. 5.Those who refuse to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Flow-mediated vasodilation function;Cardiopulmonary fitness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate and blood pressure responses during exercise.;Psychological scales, sleep scales, and quality of life scales.;Skeletal muscle mass;HRV during exercise;Other indicators: Psychological scales, sleep scales, quality of life scales, Inbody, renal function indicators, ET-1, NO, VEGF, and inflammatory response markers; | — |
Countries
China
Contacts
Public ContactWu Xin
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed