Effect of Preoperative Dexmedetomidine Nasal Spray Administration onPostoperative Quality of Recovery in Patients Undergoing Breast CancerSurgery

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600116592

Enrollment

Unknown

Registered

2026-01-12

Start date

2026-01-12

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast tumor

Interventions

Dexmedetomidine nasal spray group:None

No or saline group:None

Eligibility

Sex/Gender

Female

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1. Age: 18 to 64 years old 2.ASA classification I-III 3.It is planned to undergo elective breast tumor resection 4.Body mass Index (BMI) : 18-30 kg/m² 5.Preoperative anxiety patients (SAI>40 points) 6.Sign the informed consent form

Exclusion criteria

Exclusion criteria: 1. Individuals with known hypersensitivity to dexmedetomidine or other a2 receptor agonists 2. Severe cardiac, hepatic, or renal impairment 3. Patients scheduled to receive other preoperative sedatives (e.g., midazolam) 4. Patients with pre-existing sick sinus syndrome, severe sinus bradycardia (heart rate = III. 5. Patients unsuitable for nasal spray administration, e.g. those with severe rhinitis or nasal anatomical abnormalities.

Design outcomes

Primary

Measure	Time frame
Postoperative Quality of Recovery Scale (QoR-15);	—

Secondary

Measure	Time frame
Postoperative Quality of Recovery Scale (QoR-15);The incidence of postoperative early sleep disorder (PSD);Postoperative pain score;hemodynamic change;The duration of the surgery, the dosage of propofol or remimazolam and remifentanil used during the operation;Recovery from anesthesia;Preoperative anxiety level;Anxiety Visual Analogue Scale (VAS);adverse event;The incidence of nausea and vomiting;	—

Measure

Time frame

Postoperative Quality of Recovery Scale (QoR-15);The incidence of postoperative early sleep disorder (PSD);Postoperative pain score;hemodynamic change;The duration of the surgery, the dosage of propofol or remimazolam and remifentanil used during the operation;Recovery from anesthesia;Preoperative anxiety level;Anxiety Visual Analogue Scale (VAS);adverse event;The incidence of nausea and vomiting;

—

Countries

China

Contacts

Public ContactFei Lin

Guangxi Medical University Cancer Hospital

linfei@gxmu.edu.cn+86 137 0788 6172

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026