Cognitive deficit
Conditions
Interventions
Control group:Sham TMS group: Undergo the same procedure as Group A, but use a sham coil that produces a similar sound without delivering a magnetic field, to maintain blinding.
Intervention group:True TMS group: Receive robot-assisted, neuronavigated true transcranial magnetic stimulation (TMS) targeting the point of strongest fiber connectivity between the primary visual co
Sponsors
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 45 years; 2.Right-handed; 3.Meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for bipolar disorder and are currently in a euthymic/stable remission phase; 24-item Hamilton Depression Rating Scale (HAMD-24) score < 8; 4.Young Mania Rating Scale (YMRS) score <= 7; 5.The participant and his/her legal guardian are willing to comply with the treatment procedures and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1.Diagnosis of another primary psychiatric disorder judged by the investigators to be the predominant condition, with functional impairment exceeding that attributable to bipolar disorder; 2.Comorbid psychiatric disorders, including obsessive–compulsive disorder, personality disorders, anxiety spectrum disorders, intellectual disability, or substance use (dependence/abuse); 3.Inability to complete self-report symptom rating scales or the CANTAB cognitive assessment; 4.Prominent suicidal ideation (item 3 of the 24-item Hamilton Depression Rating Scale [HAMD-24] >= 2); 5.A clear risk of self-harm or harm to others; 6.History of severe physical illness or other medical conditions that may affect the central nervous system; 7.Neurological disorders or risk factors for seizures, such as a history of intracranial disease, head injury, abnormal electroencephalogram (EEG) findings, magnetic resonance imaging (MRI) evidence of structural brain abnormalities, or a family history of epilepsy; 8.Contraindications to MRI or transcranial magnetic stimulation, such as the presence of metallic or electronic implants (e.g., intracranial metallic foreign bodies, cochlear implants, cardiac pacemakers, vascular stents); 9.Receipt of electroconvulsive therapy (ECT) within 6 months prior to study enrollment; 10.Currently undergoing transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), or other neuromodulatory interventions; 11.Pregnant or breastfeeding women, and women of childbearing potential with a positive urine pregnancy test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-Rating Anxiety Scale (SAS);Cambridge Neuropsychological Test Automated Battery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale (HAMD);Hamilton Anxiety Scale;Self-Rating Depression Scale (SDS);Adverse Event Recording Form;Young Mania Rating Scale (YMRS);Magnetic resonance imaging;Self-Report Questionnaire for Cognitive Deficits; | — |
Countries
China
Contacts
Public ContactZhou Hetong
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed