Advanced and recurrent metastatic cervical cancer.
Conditions
Interventions
Advanced stage (stage II-IVA) :N/A
Late stage (stage IVB and recurrent metastatic) :N/A
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Cervical cancer (any histological type) confirmed by pathological diagnosis; 2.Including patients with clinical staging of stage II-IVA, stage IVB, and recurrent metastatic cervical cancer; 3.PCR testing of cervical exfoliated cells or serum confirmed positive for high-risk HPV genotypes; 4.Patients receive anti-tumor treatment according to clinical guidelines; 5.Blood samples are collected before, during, after treatment, and during follow-up, with 0.5 ml of plasma/serum per sample; 6.Blood samples are from clinically remaining samples and stored in a biobank; 7.KPS score >= 70; 8.Age 18-80; 9.ECOG performance status score 0-2; 10.patients with follow-up conditions.
Exclusion criteria
Exclusion criteria: 1.Cervical cancer patients with no pathological support for the primary lesion; 2.Those in whom double primary or multiple primary cancers cannot be excluded; 3.Patients with a history of or current other malignant tumors; 4.low-risk HPV infection; 5.PCR testing for HPV typing in cervical cancer tissue, cervical exfoliated cells, and serum all show HPV negative; 6.Patients whom the investigator deems unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum/Plasma HPV Cell-Free DNA (cfDNA); | — |
Countries
China
Contacts
Public ContactZhuomin Yin
Zhejiang Cancer Hospital
Outcome results
None listed