Perioperative analgesia
Conditions
Interventions
Morphine group:Epidural morphine:After induction, 3 mg of morphine is diluted with 0.9% saline to 10 ml for epidural administration
postoperative epidural analgesia is administered as follows: Morphine group (Group M): 0.12% ropivacaine + morphine (20 µg/mL) + saline to a total volume of 250 mL
Hydromorphone group:Epidural hydromorphone:After induction, 0.6 mg of hydromorphone was diluted with 0.9% saline to 10 ml for epidural use. Postoperative epidural analgesia was administered as follows
Sponsors
Zhongshan Hospital,Fudan University(Xiamen Branch)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing elective thoracic or upper abdominal surgery; 2.Planned postoperative thoracic epidural analgesia; 3.American Society of Anesthesiologists (ASA) physical status I-III; 4.Age: 18-80 years, gender not specified; 5.Patients provide informed consent and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Abnormal liver and kidney function: total bilirubin>3 times the upper limit or alanine aminotransferase and aspartate aminotransferase>5 times the upper limit, elevated blood creatinine = 3 times the baseline value; 2.Contraindications for epidural puncture (such as coagulation dysfunction, puncture site infection, severe spinal deformities); 3.Long term use of opioid drugs or chronic pain syndrome; 4.Preoperative cognitive impairment; 5.Mental and psychological disorders; 6.Alcohol and drug abuse; 7.The drug allergies involved in this experiment; 8.The patient refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction incidence rate;NRS score;Usage of analgesia pump;Epidural removal time and reason for removal;Intraoperative drug usage;Rehabilitation quality-related indicators (postoperative hospitalization duration, time to first bowel movement and gas exhaust, and time to first ambulation);Patient satisfaction with analgesia;Time to first PCEA; | — |
Countries
China
Contacts
Public ContactLiang Chao
Zhongshan Hospital,Fudan University(Xiamen Branch)
Outcome results
None listed