rectal cancer
Conditions
Interventions
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion Criteria for Retrospective Cohort (1) Aged 18–80 years; (2) ECOG performance status score of 0–2; (3) Pathologically confirmed adenocarcinoma; (4) Baseline rectal MRI indicating that the tumor is located at or below the peritoneal reflection; (5) Baseline assessment of cTanyNanyM0, with receipt of radical surgical treatment or neoadjuvant chemoradiotherapy; (6) Availability of rectal MRI data from our hospital for the patient. 2.In addition to the above criteria, the inclusion criteria for prospective cohort also require informed consent from patients.
Exclusion criteria
Exclusion criteria: 1.Exclusion Criteria for Retrospective Cohort (1) Comorbidity with other diseases or a history of surgery that affects anorectal function, such as pelvic floor dysfunction, perianal diseases (inflammatory bowel disease, anal fistula, anal trauma, etc.); (2) Previous history of pelvic radiotherapy; (3) Receipt of surgical procedures that do not preserve the anus and require permanent stoma creation (e.g., abdominoperineal resection); (4) Language/cognitive impairment or inability to cooperate with follow-up; (5) Inability to reverse the protective stoma due to tumor recurrence, metastasis, poor physical condition, or other reasons; (6) Deceased patients. 2. Exclusion Criteria for Prospective Cohort Items (1), (2), (3), (4), and (5) from the above exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence rate of severe LARS; | — |
Secondary
| Measure | Time frame |
|---|---|
| LARS score, Wexner incontinence score, and the core quality of life questionnaire (EORTC QLQ-C30);Anorectal manometry results;Rectal MRI imaging features; | — |
Countries
China
Contacts
Public ContactXiao Yi
Peking Union Medical College Hospital
Outcome results
None listed