Osteoporosis, Knee Osteoarthritis
Conditions
Interventions
Non-Osteoporosis Group:Osteoporosis (BMD T-score > -2.5)
Osteoporosis Group:Osteoporosis (BMD T-score <= -2.5)
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age: 50–80 years old. 2.Underwent knee X-ray examination at our hospital during the specified period, meeting the radiographic diagnostic criteria for knee osteoarthritis (Kellgren-Lawrence grade >= 2). 3.Completed dual-energy X-ray absorptiometry (DXA) bone mineral density testing during the same period, with complete lumbar spine and hip BMD data available. 4.Possession of complete medical records, including demographic information, comorbidities, medication history, and follow-up records.
Exclusion criteria
Exclusion criteria: 1.Presence of other joint diseases, including osteoarthritis at other sites (hip osteoarthritis, lumbar osteoarthritis), rheumatoid arthritis, gouty arthritis, or infectious arthritis. 2.History of prior knee surgery or intra-articular injection therapy. 3.Comorbid severe dysfunction of major organs (heart, liver, kidney) or malignancy. 4.Long-term use of glucocorticoids (prednisone-equivalent dosage >5 mg/day for >3 months) or prior use of anti-osteoporosis medications. 5.Incomplete imaging data or loss to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone mineral density (BMD);Kellgren-Lawrence grade;Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic and Clinical Characteristics;Inflammation and Metabolic Indicators; | — |
Countries
China
Contacts
Public ContactXisheng Weng
Peking Union Medical College Hospital
Outcome results
None listed