Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Patients meeting the COPD diagnostic criteria in the "Guidelines for the Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease (2021 Revised Edition)" must demonstrate airflow limitation at GOLD 2-3 levels, be in an acute exacerbation phase, and have an age range of 18 to 75 years.
Exclusion criteria
Exclusion criteria: 1. Concurrent conditions including bronchiectasis, diabetes mellitus, or systemic disorders such as cardiac, hepatic, or renal diseases; 2. Lower limb dysfunction rendering patients incapable of completing the 6-minute walk test; 3. Giant pulmonary bullae; 4. Malignant hypertension; 5. Presence of cognitive impairment; 6. Concurrent malignant tumors; 7. Acute cerebrovascular events (e.g., cerebral infarction or hemorrhage) occurring within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6-minute walking distance (6MWD);COPD Assessment Test (CAT) score;Modified British Medical Research Council (mMRC) dyspnea scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Forced expiratory volume in 1 second (FEV1);Forced vital capacity (FVC);FEV1/FVC;Self-rating Depression Scale (SDS) score;Self-rating Anxiety Scale (SAS) score;Incidence of adverse events; | — |
Countries
China
Contacts
Henan Provincial People’s Hospital