Laparoscopic gynecological surgery
Conditions
Interventions
Control group (Group A):After anesthesia induction, intravenous infusion of isotonic normal saline was initiated.
The dexmedetomidine group (Group B):After anesthesia induction, intravenous infusion of dexmedetomidine at 0.4 µg/kg/h and an equal volume of normal saline was administered until ten minutes before th
Esketamine group (Group C):After anesthesia induction, intravenous infusion of esketamine at a rate of 0.3 mg/kg/h was administered along with an equal volume of normal saline until ten minutes before
The dexmedetomidine combined with esketamine group (Group D):After anesthesia induction, intravenous infusion of esketamine at 0.3 mg/kg/h and dexmedetomidine at 0.4 µg/kg/h was administered until ten
Sponsors
Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian )
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age between 18 years and 65 years; (2) BMI ranging from 18.5 to 28 Kg/m^2; (3) Preoperative PSQI score less than 7 points; (4) ASA classification as grade I to II; (5) Elective surgery; (6) No allergy to trial-related drugs.
Exclusion criteria
Exclusion criteria: (1) Those with diagnosed mental disorders or intellectual disabilities before the surgery; (2) Patients who cannot complete the self-assessment questionnaire or cannot cooperate with follow-up due to various reasons; (3) Patients who were under drug-induced hypnosis before the surgery; (4) Patients with bradycardia or atrioventricular conduction block before the surgery; (5) Patients with a high risk of severe hypertension or intracranial pressure elevation before the surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Ainsworth Insomnia Scale on the 1st and 3rd days after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| On the first day after the surgery, QoR-15;Extubation time;Usage of vasoactive drugs during the operation;The total dose of propofol and remifentanil used during the operation;Postoperative VAS score;Preoperative and postoperative Lac and Glu blood gas values;Heart rate (HR) and mean arterial pressure (MAP) before the operation, 5 minutes, 15 minutes, and 30 minutes after extubation; | — |
Countries
China
Contacts
Public ContactWang Qiufen
Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian )
Outcome results
None listed