Emergence Agitation
Conditions
Interventions
Remimazolam Group:Intraoperative maintenance with remimazolam at 0.2 mg/kg/h
Control Group:Intraoperative maintenance with normal saline at 0.4 ml/kg/h
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients aged 18–65 years scheduled to undergo oral general anesthesia surgery; 2. ASA physical status I to III.
Exclusion criteria
Exclusion criteria: 1. Patients with comorbid neuropsychiatric or mental health disorders; 2. Long-term use of psychoactive drugs and recent history of drug abuse; 3. Patients with severe respiratory failure, bronchial asthma, severe hypertension, liver or kidney dysfunction (Child-Pugh class C or undergoing renal replacement therapy), or severe cardiovascular disease; 4. Subjects who have participated in other clinical trials within the past 4 weeks; 5. Patients with contraindications or a history of allergies to the drugs used in the study protocol; 6. Patients scheduled for tracheostomy or retention of a tracheal tube after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emergence time;Incidence of emergence agitation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain scores at rest and while coughing;Analgesic usage;Incidence of postoperative nausea and vomiting (PONV);Rescue antiemetics usage;Incidence of postoperative sleep disturbance;Length of PACU stay;Length of postoperative hospital stay;Quality of postoperative recovery;Incidence of perioperative adverse events;Patient satisfaction; | — |
Countries
China
Contacts
Public ContactLiu Huayue
The First Affiliated Hospital of Soochow University
Outcome results
None listed