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The efficacy of personalized local anesthetic dosing based on ultrasound-measured nerve cross-sectional area in brachial plexus block: a non-inferiority randomized controlled trial.

The efficacy of personalized local anesthetic dosing based on ultrasound-measured nerve cross-sectional area in brachial plexus block: a non-inferiority randomized controlled trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600116525
Enrollment
Unknown
Registered
2026-01-12
Start date
2026-02-01
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Upper limb fracture

Interventions

Experimental group (CSA group):The cross-sectional area (CSA) of the brachial plexus is measured under the ultrasound short-axis section. Using 0.5% ropivacaine, the injection volume was calculated ba
Control group 1 (empirical group):0.5% ropivacaine is used, and the injection volume is determined by the on-call anesthesiologist based on clinical experience.
Control group 2 (regroup):Using 0.5% ropivacaine, the required dose is calculated at 2.5 mg/kg.
Pre-experimental group:Sequential BCD-UDM Design with Bias Curve, Centred Isometric Regression Method for MEV90 (Measurement Coefficient) .Initial Dose Coefficient: 0.3 mL/mm2 (0.5% Ropivacaine)Stepwi

Sponsors

North Jiangsu People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Age 18–80 years old, proposed for elective unilateral upper extremity surgery; 2.ASA grade I–III; 3.Planned to undergo ultrasound-guided interscalene sulcus brachial plexus block; 4.Normal preoperative respiratory function; 5.No history of neck surgery; 6.No use of drugs that affect nerve conduction or opioids within 30 days prior to surgery

Exclusion criteria

Exclusion criteria: 1.Local infection, coagulation dysfunction, neuropathy; 2.Allergy to ropivacaine or amide local anesthetics; 3.Severe hepatic and renal insufficiency; 4.Pregnancy or lactation; 5.Expected dosing required to exceed the maximum safe single safe dose of ropivacaine; 6.Inability to cooperate with ultrasound measurements or nerve block operators.

Design outcomes

Primary

MeasureTime frame
Block success rate;

Secondary

MeasureTime frame
Block quality (whether salvage block and dose are needed);PACU VAS pain score;Changes in diaphragm function;

Countries

China

Contacts

Public ContactGao Ju

North Jiangsu People's Hospital

doctor2227@163.com+86 180 5106 3988

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026