Acute Postoperative Pain and Postoperative Rehabilitation
Conditions
Interventions
Experimental group:Administer 0.25 mg/kg of esketamine 5 minutes before skin incision, and continuously infuse it at a rate of 0.25 mg/kg/h during the operation until skin suture.
Control group:Administer an equivalent dose of normal saline 5 minutes before skin incision, and continuously infuse the same dose of normal saline during the operation.
Sponsors
General Hospital of the Eastern Theatre of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) American Society of Anesthesiologists (ASA) physical status classification of I - III 2) Age ranging from 18 to 85 years old 3) Scheduled for hip replacement surgery under general anesthesia 4) Signed the informed consent form
Exclusion criteria
Exclusion criteria: 1) Refusal to participate 2) Known allergy or hypersensitivity to the study drug (esketamine) 3) Contraindications to esketamine, such as poorly controlled hypertension over a long period, unstable ischemic heart disease, increased intracranial pressure or intraocular pressure, etc. 4) Severe hepatic dysfunction (Child - Pugh class C and D) 5) Renal failure (requiring renal replacement therapy) 6) Daily use of benzodiazepines or opioids within 1 month or intermittent use within 3 months 7) History of drug or alcohol abuse 8) Language and cognitive impairment 9) Body Mass Index (BMI) >= 30 kg/m² or <= 15 kg/m²
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The consumption of hydromorphone (converted to morphine milligram equivalent, MMSE); | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting and movement pain scores (Numeric Rating Scale, NRS);Quality of Recovery - 15 (QoR - 15) score;Quality of Recovery - 15 (QoR - 15) score;Score of the Hip Joint System Function (Harris);Score of the Athens Insomnia Scale (AIS);Intraoperative hemodynamics;The satisfaction levels of anesthesiologists ;The consumption of drugs during the operation;The first pressing time of PICA;Incidence of postoperative adverse reactions;The time of tracheal tube extubation;Time to get out of bed;Discharge time;The number of presses of PCIA;The satisfaction of surgeons;The satisfaction of patients; | — |
Countries
China
Contacts
Public ContactLidong Zhang
General Hospital of the Eastern Theatre of the Chinese People's Liberation Army
Outcome results
None listed