Postoperative Cognitive Dysfunction
Conditions
Interventions
Propofol group:Propofol Group Anesthesia Protocol:
Induction was achieved with intravenous propofol (1.5 mg/kg), sufentanil (0.2–0.4 µg/kg), and rocuronium (0.6 mg/kg). Anesthesia was maintained with
Ciprofol:Ciprofol Group Anesthesia Protocol:
Induction was achieved with intravenous sufentanil (0.2–0.4 µg/kg), ciprofol (0.4 mg/kg), and rocuronium (0.6 mg/kg). Anesthesia was maintained with contin
Sponsors
Liaoning Cancer Hospital & Institute
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Patients scheduled to undergo video-assisted thoracoscopic surgery (VATS) lobectomy; (2) Patients willing to receive total intravenous anesthesia; (3) Patients aged between 65 and 80 years, with a body mass index (BMI) between 18 kg/m² and 30 kg/m²; (4) Patients classified as American Society of Anesthesiologists (ASA) physical status I or II; (5) Patients with no history of surgery within the past 3 months.
Exclusion criteria
Exclusion criteria: (1) Patients with a known allergy to any anesthetic drug used in this study; (2) Patients with a history of alcohol, sedative-analgesic, psychotropic substance abuse, or drug addiction; (3) Patients unable to cooperate with or complete the Mini-Mental State Examination (MMSE), or whose score falls below the specified thresholds (illiterate <= 17, primary school education <= 20, secondary school education <= 22, college education or above <= 23); (4) Patients with severe concomitant diseases, including significant cardiac, pulmonary, hepatic, renal, or endocrine disorders; (5) Patients currently taking sedative-opioids, sleep aids (e.g., benzodiazepines), or antidepressant medications (e.g., tricyclic, tetracyclic antidepressants, or selective serotonin reuptake inhibitors); (6) Patients who decline to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative cognitive dysfunction (POCD);Quality of postoperative recovery;Hemodynamics; | — |
Countries
China
Contacts
Public ContactLi Songze,Hou baoxu
Liaoning Cancer Hospital & Institute
Outcome results
None listed