Inflammatory bowel disease
Conditions
Interventions
adjacent normal intestine:None
inflamed intestinal tissue:None
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients clinically diagnosed with IBD, including Crohn’s disease or ulcerative colitis; 2.Patients who have undergone surgical resection of diseased intestinal segments at our hospital, with complete surgical pathology specimens available; 3.Specimens in which areas of active inflammation can be clearly distinguished from relatively normal or peri-inflammatory intestinal segments; 4.Specimens with good preservation quality and suitable for immunohistochemistry or immunofluorescence analysis; 5.Complete clinical data available for the patient, including age, sex, medical history, medication history, pathological diagnosis, and other key information;
Exclusion criteria
Exclusion criteria: 1.Specimens obtained from non-IBD patients (e.g., those with tumors, infectious colitis, etc.); 2.Tissue specimens lacking complete pathological information or with severely damaged tissue architecture, making effective staining and analysis impossible; 3.Specimens lacking clearly defined areas of active inflammation or corresponding control regions, making comparative analysis unfeasible; 4.Patients with severe comorbidities (e.g., other autoimmune diseases, primary hepatobiliary disorders) that may interfere with the assessment of bile acid metabolism or receptor expression; 5.Inability to obtain key clinical information from the patient, or cases with severely incomplete clinical data;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| H-score or fluorescence intensity of intestinal tissue; | — |
Countries
China
Contacts
Public ContactRenke Yu
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed