Cervical intraepithelial neoplasia
Conditions
Interventions
Index test:Cervical methylation testing
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Voluntary participation in this study; 2.Aged 18-65 years; 3.Patients with cervical biopsy-confirmed cervical lesions (CIN?-CIN?) , scheduled for cervical conization via Loop Electrosurgical Excision Procedure (LEEP); 4.Availability of pre-enrollment test results within 3 months: High-risk HPV genotyping test Cervical exfoliative cytology test (Pap smear) Serum SCC antigen test Colposcopy examination Preoperative/Postoperative cervical biopsy pathology reports; 5.Carried out the collection and testing of six gene methylation specimens at the outpatient department; 6.Be able to follow the visit and related procedures as stipulated in the plan;
Exclusion criteria
Exclusion criteria: 1. Women during pregnancy or lactation period; 2. Those without surgical indications; 3. Cervical cancer patients; 4.Previously, physical therapy or surgical treatment, radiotherapy and chemotherapy were performed due to cervical lesions or cervical cancer. 5.The researchers believe that any situation that might increase the risk for the subjects; 6.Those who are unable to complete the treatment course;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Methylation test results: Positive and negative as well as scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic data: sex, age, etc.;Clinical Diagnosis: Collect pathological grading results, type of cervical transformation zone, lesion size under colposcopy, etc.;Association between cone biopsy results and methylation levels; | — |
Countries
China
Contacts
Public ContactJia Ying
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed