Asthma
Conditions
Interventions
Susceptible population group:None
Healthy control population:None
Positive control group (asthma group):None
Sponsors
The Second Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Population at Risk for Asthma: (1) Age: 18–75 years; (2) Registered population, gender unrestricted, recruited from community or outpatient/emergency departments; (3) Presence of at least one of the aforementioned respiratory symptoms and/or exposure to risk factors; (4) Completion of pulmonary function tests (including IOS), bronchodilator response test, and bronchial challenge test (with or without obstructive ventilatory dysfunction); (5) Signed informed consent form, willingness to participate in the study according to the protocol, and commitment to complete at least 3 years of follow-up. Note: Subjects with acute respiratory events during screening may be enrolled one month after clinical stabilization. 2. Healthy Control Group: (1) Age: 18–75 years; (2) Registered population, gender unrestricted, recruited from community or outpatient/emergency departments; (3) Absence of the aforementioned respiratory symptoms and/or exposure to risk factors; (4) Completion of pulmonary function tests (including IOS), bronchodilator response test, and bronchial challenge test (with or without obstructive ventilatory dysfunction); (5) Signed informed consent form, willingness to participate in the study according to the protocol, and commitment to complete at least 3 years of follow-up. 3. Asthma Control Group: (1) Age: 18–75 years; (2) Registered population, gender unrestricted, recruited from community or outpatient/emergency departments; (3) Diagnosis of bronchial asthma according to criteria (reference: "Guidelines for the Prevention and Treatment of Bronchial Asthma (2020 Edition)"); (4) Completion of pulmonary function tests (including IOS), bronchodilator response test, and bronchial challenge test (with or without obstructive ventilatory dysfunction); (5) Signed informed consent form, willingness to participate in the study according to the protocol, and commitment to complete at least 3 years of follow-up.
Exclusion criteria
Exclusion criteria: 1. Population at Risk for Asthma: (1) Age 75 years; (2) Respiratory symptoms clearly caused by active tuberculosis, silicosis, fungal infection, bronchial tumors; or clinically diagnosed diseases affecting study outcomes such as lung cancer, pneumoconiosis, bronchiectasis, interstitial lung disease, or known causes of isolated restrictive ventilatory dysfunction; (3) Patients with prior lung resection; (4) Patients with contraindications to spirometry, bronchodilator response test, or bronchial challenge test; (5) Psychiatric disorders or cognitive impairment preventing understanding of the study; or other chronic diseases potentially interfering with study outcomes; (6) Pregnant or lactating females; (7) Any other factors affecting follow-up or compliance. 2. Healthy Control Group: (1) Age 75 years; (2) Clinically diagnosed diseases affecting study outcomes such as lung cancer, pneumoconiosis, bronchiectasis, interstitial lung disease, or known causes of isolated restrictive ventilatory dysfunction; (3) Patients with prior lung resection; (4) Patients with contraindications to spirometry, bronchodilator response test, or bronchial challenge test; (5) Psychiatric disorders or cognitive impairment preventing understanding of the study; or other chronic diseases potentially interfering with study outcomes; (6) Pregnant or lactating females; (7) Any other factors affecting follow-up or compliance. 3. Asthma Control Group: (1) Age 75 years; (2) Clinically diagnosed diseases affecting study outcomes such as lung cancer, pneumoconiosis, bronchiectasis, interstitial lung disease, or known causes of isolated restrictive ventilatory dysfunction; (3) Patients with prior lung resection; (4) Patients with contraindications to spirometry, bronchodilator response test, or bronchial challenge test; (5) Psychiatric disorders or cognitive impairment preventing understanding of the study; or other chronic diseases potentially interfering with study outcomes; (6) Pregnant or lactating females; (7) Any other factors affecting follow-up or compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asthma occurrence (date of first diagnosis, severity, and control status);Changes in pulmonary function omics (including IOS), radiomics, and clinical multi-omics biomarkers; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical symptoms, acute respiratory events, and quality of life scores, etc.; | — |
Countries
China
Contacts
Public ContactLan Fen
The Second Affiliated Hospital of Zhejiang University School of Medicine
Outcome results
None listed