sepsis
Conditions
Interventions
High-level HA/HYALs Group:None
Low-level HA/HYALs Group:None
Sponsors
Yancheng First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria of the "Surviving Sepsis Campaign (SSC): International Guidelines for the Management of Sepsis and Septic Shock 2021"; 2. Age >= 18 years; 3. ICU stay >= 48 hours; 4. Family members or patients voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding women; 2. Patients with severe chronic kidney disease (such as hypertensive nephropathy, diabetic nephropathy, chronic nephritis, etc.); 3. Post-kidney transplant patients; 4. Patients with malignant tumors (including any type, origin, or stage of malignant tumor); 5. Patients with hematologic diseases, immune system disorders, or immunodeficiency; 6. Patients with AKI not caused by sepsis (such as urinary obstruction, major surgery, severe trauma, nephrotoxic drugs, contrast exposure, etc.); 7. Patients who received hyaluronic acid treatment within 24 hours prior to enrollment (such as intra-articular injection); 8. Patients who already had AKI at the time of enrollment; 9. Patients who refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of 7-day AKI in enrolled patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day mortality; | — |
Countries
China
Contacts
Public ContactMu Genhua
Yancheng First People's Hospital
Outcome results
None listed