stroke
Conditions
Interventions
Healthy Control Group:None
Sponsors
The First Affiliated Hospital Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patient Group: 1. Age >=18 years and =6 at admission. 5. Diffusion-weighted imaging (DWI) Alberta Stroke Program Early CT Score (ASPECTS) >=6. 6. Patients possess the ability to communicate, understand, and provide informed consent, and can follow the trial schedule. 7. Good patient compliance, able to cooperate with and complete post-procedure follow-up requirements. Healthy Control Group: 1. Age >=18 years and <=90 years, sex-matched to the patient group. 2. No history of acute ischemic stroke or transient ischemic attack (TIA). 3. No history of other severe neurological diseases. 4. No severe systemic diseases. 5. No history of acute infection, fever, or major trauma/surgery within the past month. 6. No psychiatric disorders or cognitive impairment; able to comprehend the study content and cooperate with completing assessments. 7. Voluntary participation and provision of written informed consent.
Exclusion criteria
Exclusion criteria: Patient Group: 1. Occurrence of adverse outcomes prior to the first sample collection. 2. Significant pre-stroke disability (pre-stroke modified Rankin Scale [mRS] score >= 2). 3. Intracranial hemorrhage, subarachnoid hemorrhage, arteriovenous malformation, aneurysm, or intracranial tumor confirmed by CT/MRI upon admission. 4. Pre-existing neurological or psychiatric conditions that may interfere with neurological assessment. 5. History of active or recent bleeding, trauma, or surgery within 2 months prior to stroke onset. 6. Concurrent infection at the time of sample collection. 7. Presence of rheumatoid/autoimmune diseases, severe liver/kidney diseases, hematological disorders, or malignant tumors. 8. Suspected septic emboli or bacterial endocarditis. 9. Pregnancy or lactation. 10. Incomplete clinical, imaging, follow-up, or laboratory data. Healthy Control Group: 1. Presence of rheumatoid/autoimmune diseases, severe liver/kidney diseases, hematological disorders, malignant tumors, or other acute/chronic inflammatory diseases such as infections. 2. History of major surgery, severe trauma, or active bleeding in the recent past. 3. Pregnancy or lactation. 4. Cognitive or communication impairments that preclude completion of basic assessments. 5. Any other condition deemed inappropriate for serving as a healthy control by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 90-day mRS score after EVT; | — |
Secondary
| Measure | Time frame |
|---|---|
| Early neurological deterioration (END);Neutrophil Extracellular Traps (NETs);Montreal Cognitive Assessment (MoCA);Mini-Mental State Examination (MMSE);Hamilton Depression Rating Scale (HAMD);Hamilton Anxiety Rating Scale (HAMA);Interleukin (IL);Tumor Necrosis Factor (TNF);4-Hydroxynonenal (4-HNE);Aldehyde Dehydrogenase 2 rs671 genotype (ALDH2 rs671 genotype);MDA;High Mobility Group Box 1 Protein; | — |
Countries
China
Contacts
Public ContactPeng Zhou
The First Affiliated Hospital Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)
Outcome results
None listed