Anesthesia for elderly patients
Conditions
Interventions
experimental group:In the experimental group, esketamine at a dose of 0.25 mg/kg was intravenously injected during the general anesthesia induction, and then 0.1 mg/(kg·h) of esketamine was continuous
Control group:Use an equal volume of normal saline instead of esketamine, with all other medications and anesthesia protocols the same as the experimental group (Esk group).
Sponsors
Henan Provincial Third People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1 Age >= 65 years old, able to tolerate general anesthesia and surgery, and willing to undergo at least 1-year follow-up; 2 Body mass index between 18 - 30 kg/m^2; 3 American Society of Anesthesiologists (ASA) classification of grades I - III.
Exclusion criteria
Exclusion criteria: 1 Uncontrolled severe systemic diseases (such as severe cardiovascular and cerebrovascular diseases, infections, coagulation disorders, etc.); 2 Cognitive dysfunction, mental illness or a history of delirium before the surgery, which affects the postoperative assessment; 3 Severe liver or kidney dysfunction; 4 Alcohol or drug dependence; 5 Allergic to the drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative VAS pain score, total dosage of sufentanil used;Total dosage of sufentanil used; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative sleep score;The incidence rates of adverse reactions such as postoperative nausea, vomiting, dizziness, and hallucinations; | — |
Countries
China
Contacts
Public ContactAn Jing
Henan Provincial Third People's Hospital
Outcome results
None listed