Pre-Pregnancy Overweight and Obesity
Conditions
Interventions
Standard Nutrition Guidance Group:Receive routine prenatal nutrition management at the hospital. Based on the Chinese Dietary Guidelines for residents and the latest clinical diagnosis and treatment s
for obese women (BMI >=28 kg/m^2), 1,600–1,800 kcal/day
protein intake is 1.1 g/kg/day, fat 25–35%, and carbohydrates 45–55%, following the pregnancy edition of the 'Chinese Dietary Guidelines for Residents,' emphasizing dietary diversity without the need
Hypocaloric Diet Intervention Group:Follow an individualized low-calorie dietary plan, reducing energy intake by 20–30% compared to the conventional pregnancy recommendations, while ensuring protein >
Sponsors
Obstetrics and Gynecology Hospital Affiliated to Tongji University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Singleton pregnancy, including early, mid, and late stages; 2. Ages 19-40; 3. Pre-pregnancy BMI >=24; 4. Signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of infectious diseases: HIV, hepatitis B or C, history of active pulmonary tuberculosis or active pulmonary tuberculosis; 2. Secondary metabolic dysfunction, such as Cushing's syndrome, hypothyroidism, acromegaly, hypothalamic obesity, polycystic ovary syndrome, etc.; 3. History of malignant tumors; 4. Severe liver dysfunction (aspartate aminotransferase or alanine aminotransferase more than 3 times the upper limit of normal) or chronic kidney disease (estimated glomerular filtration rate < 30 ml/min/1.73m²), or history of severe cardiovascular or cerebrovascular disease within the past 6 months to pregnancy, or history of severe gastrointestinal disease or gastrointestinal surgery within the past 12 months to pregnancy; 5. History of habitual miscarriage or multiple induced abortions; 6. History of smoking within 3 months before pregnancy to pregnancy; 7. History of taking medications that affect weight or energy intake/energy expenditure within 6 months before pregnancy to pregnancy, including weight loss drugs, antipsychotic medications, etc.; 8. Participation in a weight loss program during pregnancy, or weight change greater than 5% of current body weight in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of macrosomia;Neonatal body-fat percentage;BMI Z-score;Incidence of neurodevelopmental delay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin A1c;fasting lipid (TC,TG,HDL-C,LDL-C);fasting plasma glucose;C-Reactive Protein;Mode of delivery;Incidence of large-for-gestational-age (LGA) ;Incidence of neonatal hypoglycaemia;Incidence of shoulder dystocia;Incidence of pre-labour rupture of membranes;Post-partum blood loss;1-minute Apgar score;Umbilical-artery blood pH;NICU admission rate;Incidence of neonatal respiratory distress syndrome; | — |
Countries
China
Contacts
Public ContactQiaoling Du
Obstetrics and Gynecology Hospital Affiliated to Tongji University
Outcome results
None listed