Depressive Disorder
Conditions
Interventions
BS-aTBS group:The left DLPFC received iTBS stimulation, while the right DLPFC received cTBS stimulation.
a-iTBS group:The left DLPFC received iTBS intervention.
Sponsors
Shandong mental health center
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Aged 12–18 years, regardless of gender; 2.Meeting the diagnostic criteria for Depressive Disorder according to DSM-V; 3.Right-handed; 4.Hamilton Depression Rating Scale-17 (HAMD-17) score >= 17 at screening; 5.Normal results of electrocardiogram (ECG) and blood routine examination; 6.If the subject is taking medications, only those taking sertraline, fluoxetine, or escitalopram will be included; 7.Having a full understanding of the safety of Transcranial Magnetic Stimulation (TMS), being willing to actively cooperate with the treatment, and signing the informed consent form together with their guardian.
Exclusion criteria
Exclusion criteria: 1.History of severe physical diseases, or depression caused by other psychoactive substances and non-dependent substances; 2.Having implanted metals or electronic devices in the body, such as intracranial metallic foreign bodies, cochlear implants, cardiac pacemakers, stents, or other metallic foreign bodies; 3.Patients with a past or current diagnosis of severe mental illnesses, including schizophrenia, bipolar disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), generalized anxiety disorder (GAD), panic attacks, or eating disorders; 4.Patients at risk of epileptic seizures, including those with a history of craniocerebral diseases, head trauma, alcoholism, abnormal electroencephalogram (EEG), magnetic resonance imaging (MRI) evidence of abnormal brain structure, or a family history of epilepsy; patients with a past history of craniocerebral surgery who are deemed unsuitable for the study by the researchers; 5.Those who have received modified electroconvulsive therapy (MECT) within 6 months before enrollment; 6.Patients with psychotic symptoms requiring combined use of antipsychotic drugs; 7.Patients who have participated in other interventional clinical trials within 3 months; 8.Claustrophobia and other contraindications to MRI; 9.Other conditions deemed unsuitable for participation in the trial by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in HAMD-17 scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Suicide idea;Remission rate;Effectiveness;Changes in HAMA scores;Self-assessment score for depression and anxiety; | — |
Countries
China
Contacts
Public ContactDuanWei Wang
Shandong mental health center
Outcome results
None listed