Major Depressive Disorder
Conditions
Interventions
Magnetic Seizure Therapy Group:Pharmacotherapy Combined with Magnetic Seizure Therapy
MECT group:Pharmacotherapy Combined with MECT
health control group:none
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclution Criteria for depression patients: 1. Meet the diagnostic criteria for a Major Depressive Episode according to DSM-5. 2. Score > 17 on the 17-item Hamilton Depression Rating Scale (HAMD-17). 3. Aged between 18 and 60 years. 4. No abnormalities in laboratory tests (complete blood count, biochemistry) or electrocardiogram (ECG). 5. Provide written informed consent from the patient themselves, their guardian, or legal representative. Inclusion Criteria for the Healthy Control Group: 1. Age between 18 and 65 years (inclusive of 18 and 65), regardless of gender; 2. Education level above primary school, with the ability to understand the research content; 3. Generally healthy in the past, with no history of somatic diseases in the cardiovascular, respiratory, digestive, renal, endocrine, hematological, or other systems; 4. No history of mental disorders; 5. Understanding and voluntarily participating in this study, with signed informed consent provided by the participant.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for depression patients: 1. Exclusion of other psychiatric disorders meeting DSM-5 diagnostic criteria besides depression. 2. Exclusion of individuals with clinically significant abnormalities in electrocardiogram (ECG) or laboratory test results, as these may affect efficacy assessment or safety evaluation. 3. Exclusion of patients with severe concurrent cardiac, hepatic, renal, ophthalmic, neurological, endocrine, or hematological diseases that may interfere with the study or increase participation risks, as well as patients with epilepsy, malignant tumors, or traumatic brain injury. 4. Exclusion of patients with substance dependence or abuse within the past 6 months. 5. Exclusion of patients taking valproate (benzodiazepine hypnotics are permitted). 6. Exclusion of patients who have undergone Modified Electroconvulsive Therapy (MECT) within the past 6 months. 7. Exclusion of pregnant or breastfeeding women, or those planning pregnancy. 8. Exclusion of individuals with intracranial metal implants and/or cardiac pacemakers to prevent potential adverse effects of Transcranial Magnetic Stimulation (TMS). Exclusion Criteria for the Healthy Control Group: 1. Currently suffering from mental illnesses; 2. History of impaired consciousness, schizophrenia, bipolar disorder, depressive disorders, personality changes, or other mental disorders; 3. Family history of hereditary diseases; 4. Severe somatic diseases, such as endocrine system disorders or cardiovascular and cerebrovascular diseases; 5. History of alcohol/drug dependence; 6. Women who are pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in total MCCB score from baseline after completion of MST/MECT treatment.;Changes from baseline in the total scores of HAMD-17;Changes from baseline in the total scores of HAMA;Changes from baseline in the total scores of CGI;changes from baseline in all domain scores of the MCCB; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrophysiological Indices - Cortical Excitability and Neuroplasticity;Neuroimaging Indices; | — |
Countries
China
Contacts
Public ContactYingying Zhao
Beijing Anding Hospital, Capital Medical University,
Outcome results
None listed