Atherosclerosis
Conditions
Interventions
Intervention group:Perilla oil Capsules: Take 2 times a day, 3 capsules each time, 0.5g per capsule, that is, 3g capsules per day, containing ALA 3*0.68= 2.04g. The intervention period is three months
Control group:Corn oil capsules: Take 2 times a day, 3 capsules each time, 0.5g per capsule. The intervention period is 3 months.
Sponsors
Lianshui People's Hospital Affiliated to kangdacollege, Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Male or female aged 18~75 years old; 2. Patients with confirmed carotid atherosclerosis (carotid artery color ultrasound finds any abnormality in any of the carotid arteries, and carotid atherosclerosis is considered to be present, including C-IMT thickening, carotid plaque, carotid artery stenosis, etc.); 3. Voluntarily participate in this trial and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Pregnant women, lactating mothers, and those with severe complications; Those aged less than 18 or more than 75; 2. There are severe heart failure, pulmonary insufficiency, renal failure, cerebrovascular diseases, severe diabetes complications, severe hypertension complications, blood diseases, malignant tumors, and autoimmune diseases; 3. Diagnosed with concurrent alcoholic fatty liver disease, acute or chronic hepatitis, drug-induced liver injury, liver cirrhosis and other liver diseases; 4. Patients diagnosed with gallbladder stones, cholecystitis, gallbladder cancer and other biliary tract diseases, as well as those with a history of cholecystectomy; 5. Patients who have experienced infection, surgery, stress or major trauma in the past three months; 6. Have a history of allergies or have been taking n-3 PUFA nutritional supplements for a long time (in the past half year); 7. Change the lipid-lowering drug treatment plan after participating in the project; 8. People with special dietary habits such as vegetarianism or dieting for weight loss.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Carotid intima-media thinckness (C-IMT);brachial-ankle pulse wave velocity (baPWV);Total cholesterol;Triglyceride;Low-density lipoprotein cholesterol;High-density lipoprotein cholesterol;Very low-density lipoprotein cholesterol;Oxidized low-density lipoprotein cholesterol;Lipoprotein (a);Homocysteine (Hcy);Trimethylamine oxide;Bile acid profile;Feces 16S rDNA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Height;Weight;Waist circumference;Hip circumference;Alanine transaminase (ALT);Aspartate transaminase (AST);Cholinesterase (ChE);a-L-Fucosidase (AFU);Glutamate dehydrogenase;Cholyglycine;Total bilirubin (TBil);Total Protein (TP);Creatine; | — |
Countries
China
Contacts
Public ContactQiaosheng Hu
Lianshui People's Hospital Affiliated to kangdacollege, Nanjing Medical University
Outcome results
None listed