Post-mastectomy radiotherapy after modified radical mastectomy for breast cancer
Conditions
Interventions
Convention VMAT group:None
VMAT+SkinFlash group:None
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Pathologically confirmed breast cancer and having undergone unilateral total mastectomy; 2. Presence of high-risk factors such as tumour invasion of the skin or chest-wall muscles, or =4 positive axillary lymph nodes, for which post-operative chest-wall radiotherapy is indicated; 3. Flat chest-wall contour without immediate or delayed breast reconstruction; 4. Eastern Cooperative Oncology Group (ECOG) performance status 0–2, able to tolerate radiotherapy; 5. Age: 18-70 years old (inclusive), female gender. 6. Voluntary participation with signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Concurrent malignancies (except for those with excellent prognosis, e.g., basal-cell carcinoma of the skin or carcinoma in situ of the cervix); 2. Severe dysfunction of major organs (heart, lung, liver, kidney, etc.) precluding radiotherapy; 3. Chronic skin disorders (e.g., eczema, psoriasis) or active infectious skin lesions; 4. Previous thoracic radiotherapy; 5. Psychiatric, cognitive, or communication disorders precluding compliance with study procedures and follow-up; 6. Pregnancy, lactation, or intention to become pregnant during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| acute skin toxicity;Measurement dose of Skin; | — |
Secondary
| Measure | Time frame |
|---|---|
| MU number;Dose to OARs; | — |
Countries
China
Contacts
Public ContactWang Xuetao
Peking University Shenzhen Hospital
Outcome results
None listed