Hypertrophic cardiomyopathy
Conditions
Interventions
Control group :Patients in the control group were treated with mavacamten
Rehabilitation group:The intervention group added exercise rehabilitation on the basis of mavacamten treatment
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Treat patients with hypertrophic obstructive cardiomyopathy who have been on Mavacamten for at least 3 months; 2. Be willing to participate in this study; 3. Patients who report subjective fatigue symptoms, with a Fatigue Severity Scale (FSS) score of >= 36 points.
Exclusion criteria
Exclusion criteria: 1. Age less than 18 years old or greater than 80 years old;;2. Recent syncope or persistent ventricular tachycardia;3. Uncontrolled severe diabetes, hypertension patients, those with poor blood sugar control, end-stage renal disease, COPD, poor blood pressure control;4.Patients with severe arrhythmias such as atrial fibrillation, atrioventricular block, sick sinus syndrome, etc;5. Complicated with acute myocardial infarction, unstable angina pectoris, kidney diseases, hematological diseases, tumors, hyperthyroidism, severe pulmonary diseases, etc;6. Patients with heart failure and a cardiac function of grade III or above;7. Patients and their family members do not sign the informed consent form;8. Severe aortic valve, mitral valve, or tricuspid valve stenosis or insufficiency;9.Absolute contraindications for symptom-limited maximal exercise test (for patients with left ventricular outflow tract pressure difference >= 50 mmHg and LVEF < 50%, cautious exercise rehabilitation or low-intensity activity is recommended.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fatigue Severity Score (FFS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximum oxygen uptake;Muscle elastic modulus; | — |
Countries
China
Contacts
Public ContactMi Shouling
Zhongshan Hospital, Fudan University
Outcome results
None listed