liver cancer
Conditions
Interventions
Normal liver function group :None
impaired liver function group:None
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the control group (normal liver function group) : 1. Pathological diagnosis of hepatocellular carcinoma 2. Normal liver function both before and after the operation (for liver dysfunction, refer to the diagnostic criteria of this study) 3. No radiotherapy, chemotherapy, targeted therapy or other adjuvant treatments were received before the operation. 4. All were the first surgical treatments. 5.No other malignant tumors were combined; 6. Patients and their families were informed of this study and voluntarily joined it. Inclusion criteria for the case group (liver dysfunction group) : 1 The pathological diagnosis was hepatocellular carcinoma. 2. The liver function was normal before the operation. 3. The liver function was impaired after the operation. 4. No radiotherapy, chemotherapy, targeted therapy or other adjuvant therapy was received before the operation. 5. All were undergoing surgical treatment for the first time. 6. No other malignant tumors were combined. 7. Patients and their families were informed of this study and voluntarily participated in it
Exclusion criteria
Exclusion criteria: 1. Previously received TACE, chemotherapy, radiotherapy or targeted immunotherapy; 2. Total time of multiple hepatic portal occlusion during the operation > 60 minutes; 3. There are serious heart and lung diseases; 4. There is distant metastasis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The changes in APOC3 content before and after hepatic portal occlusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| One day before the operation, APOC3;One day after the operation, APOC3;One day before the operation, AST;One day after the operation, AST;One day before the operation, AST;One day after the operation, ALT;One day before the operation, LDH;One day after the operation,LDH;Total bilirubin one day before the operation;Total bilirubin one day after the operation;Coagulation function one day before the operation;Coagulation function one day after the operation; | — |
Countries
China
Contacts
Public ContactMo Jian
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed