Acute kidney injury associated with cardiopulmonary bypass cardiac surgery
Conditions
Interventions
Study group:Study group:Hemoperfusion therapy during the perioperative period of cardiac surgery with cardiopulmonary bypass
Control group:Conventional treatment during the perioperative period of cardiac surgery with cardiopulmonary bypass (without hemoperfusion)
Sponsors
Hospital of Chinese Medicine of the Xinjiang Uyghur Autonomous Region
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 80 years old, with American Society of Anesthesiologists (ASA) physical status classification ?-?. 2.Confirmed to undergo cardiopulmonary bypass (CPB) cardiac surgery . 3.Normal preoperative renal function: serum creatinine = 60 ml/(min·1.73m^2). 4.New York Heart Association (NYHA) functional classification I-III. 5.Patients and their family members are fully informed and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Preoperative chronic renal insufficiency (requiring renal replacement therapy) or a history of renal transplantation; 2.Hypersensitivity to anticoagulants (heparin); 3.Inability to complete intraoperative monitoring of urinary oxygen partial pressure or renal resistive index (RRI) (e.g., abdominal distension interfering with ultrasound examination); 4.Complicated with severe arrhythmia (second-degree or higher atrioventricular block) or left ventricular ejection fraction < 30%; 5.Complicated with severe infection (e.g., sepsis) or autoimmune disease (e.g., systemic lupus erythematosus); 6.Incomplete medical records precluding data collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine;Estimated glomerular filtration rateEstimated glomerular filtration rate;Blood urea nitrogen;Incidence of AKI after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin-6 (IL-6);Interleukin-8 (IL-8);Interleukin-10 (IL-10);Tumor necrosis factor-a (TNF-a); Urine partial pressure of oxygen (UPO?);Renal Resistance Index; | — |
Countries
China
Contacts
Public ContactTao Wu
Hospital of Chinese Medicine of the Xinjiang Uyghur Autonomous Region
Outcome results
None listed