Dry eye syndrome
Conditions
Interventions
Experimental Group:All patients were treated with iTEAR for 4 weeks, twice a day, with an interval of no less than 6 hours between each dose, and each dose lasted for 30 seconds on each side
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with DED according to the TFOS DEWS II diagnostic methodology report and the Chinese Dry Eye Expert Consensus (2024). 2. Aged between 18 and 75 years old. 3. SIT result > 5 mm/5 min. 4. No DED-related ocular surface physiotherapy within 30 days prior to screening, or discontinuation of over-the-counter artificial tears and ocular gels for at least 30 days. 5. Willingness and ability to complete all trial visits and assessments.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or lactation. 2. Intraocular surgery within 6 months prior to enrollment. 3. Clinically significant corneal or conjunctival scarring. 4. Hypersensitivity to nasal nerve stimulation (e.g., status post nasal surgery, active allergic rhinitis). 5. Active skin lesions in the nasal area. 6. Ocular malignancies or uncontrolled glaucoma. 7. Eyelid abnormalities (e.g., lagophthalmos, entropion, ectropion). 8 .Facial neuromuscular disorders. 9. History of punctal plug insertion. 10.Any other conditions deemed unsuitable by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular Surface Disease Index (OSDI) score;Fluorescein Tear Break-Up Time (FBUT);Corneal Fluorescein Staining (CFS) score;Schirmer I Test (SIT) value; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tear Interleukin-6 (IL-6) concentration;Tear Matrix Metalloproteinase-9 (MMP-9) concentration; | — |
Countries
China
Contacts
Public ContactLi Guigang
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Tongji Hospital
Outcome results
None listed