Gastric diseases caused by Helicobacter pylori infection
Conditions
Interventions
Helicobacter pylori infection negative subjects:No
Helicobacter pylori positive and asymptomatic subjects:No
Subjects with positive Helicobacter pylori infection and symptoms of chronic superficial gastritis:No
Sponsors
Beijing Chaoyang Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Age range from 18 to 60 years old (2) Diagnosed with Helicobacter pylori infection and asymptomatic or symptomatic chronic superficial gastritis; Or those who are negative for Helicobacter pylori infection and have no stomach diseases. The symptoms of chronic superficial gastritis refer to varying degrees of digestive discomfort in the subject, such as upper abdominal discomfort, dull pain after eating, accompanied by belching, nausea, acid reflux, and occasional vomiting. Asymptomatic refers to subjects who have not experienced the aforementioned digestive symptoms. Those who meet the diagnostic criteria for Hp infection in the "Guidelines for Primary Diagnosis and Treatment of Helicobacter pylori Infection (Practice Edition · 2019)", that is, those who meet one of the following three criteria, can be judged as Hp current infection: a. Positive for any one of the three tests, including rapid urease test (RUT), tissue section staining, or bacterial culture, in gastric mucosal tissue; b. 13C urease breath test (13C-UBT) or 14C-UBT shows positive for Helicobacter pylori infection. c. Fecal Hp antigen (HpSA) detection (clinically validated monoclonal antibody method) is positive; The serum Hp antibody test (a clinically validated and highly accurate reagent) is positive for individuals who have never received treatment. (3) Those who voluntarily undergo gastroscopy examination and provide gastric mucosal samples. (4) Voluntarily participate in this experiment and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Age below 18 or above 60 years old. (2) Those currently in pregnancy, lactation, or pre pregnancy. (3) Individuals with mental illnesses, immune system disorders, cardiovascular, lung, liver, kidney diseases, malignant tumors, coagulation disorders, etc. (4) Individuals with a history of treatment for Helicobacter pylori infection. (5) Individuals who have used antibiotics, probiotics, proton pump inhibitors, H2 receptor antagonists, bismuth preparations, laxatives, antidiarrheal drugs, or certain antibacterial traditional Chinese medicines within the past 4 weeks. (6) Individuals with a history of gastrointestinal surgery. (7) Other clinical doctors believe that participants are not suitable for this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composition of gastric antral microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pathological examination of gastric antrum;Gastrointestinal Clinical Symptom Assessment Form; | — |
Countries
China
Contacts
Public ContactXinjuan Liu
Department of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University
Outcome results
None listed