Repeated Implantation Failure
Conditions
Interventions
Experimental group:After intrauterine injection of exosomes for treatment, conventional estrogen therapy was performed for frozen-thawed embryo transfer
Sponsors
General Hospital of Eastern Theater Command, People's Liberation Army of China
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. 2 times of transplantation, >=2 high-quality embryos, no pregnancy; 2. Repeated miscarriages >=2 times, excluding genetic factors of the embryo; 3. Thin endometrium; 4. Age: 20-40 years old.
Exclusion criteria
Exclusion criteria: 1. Endometrial polyps or endometrial hyperplasia; 2. Those with contraindications to pregnancy or assisted reproductive technology; 3. Those with contraindications for hysteroscopic surgery; 4. Untreated uterine diseases that clearly affect the morphology of the uterine cavity (uterine malformations, submucosal fibroids, adenomyosis, endometriosis, etc.) 5. Those whose serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are twice the upper limit value; 6. Those with serum creatinine (Gr) levels higher than the upper limit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Embryo implantation rate;Early pregnancy loss rate;Continuous pregnancy rate;Live birth rate;Uterine artery blood flow pulsation index;Uterine artery blood flow resistance index;Endometrial thickness; | — |
Countries
China
Contacts
Public ContactLi Chen
General Hospital of Eastern Theater Command, People's Liberation Army of China
Outcome results
None listed