Perioperative anxiety and postoperative pain in patients with benign breast masses.
Conditions
Interventions
Dexmedetomidine Group:Patients in this group will receive nasal spray of dexmedetomidine.
Control Group:Patients in this group will receive nasal spray of saline solution.
Sponsors
Cancer Hospital Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients scheduled to undergo unilateral breast lesion excision under sedation with anesthetic monitoring; 2.aged between 18 and 70 years; 3.classified as ASA I-II; 4.with New York Heart Association (NYHA) functional class I-II; 5.and a body mass index (BMI) < 30 kg/m^².
Exclusion criteria
Exclusion criteria: 1.Patients who are deemed unsuitable for intranasal administration by the investigator, such as those with severe rhinitis, nasal polyps, or nasal deformities. 2.Patients with severe heart failure, arrhythmias, sinus bradycardia, obstructive sleep apnea syndrome, or other respiratory diseases; liver or kidney dysfunction; severe hypertension, diabetes, obesity, or other serious comorbidities. 3.Patients with a history of breast cancer surgery. 4.Patients with a history of local anesthetic allergy. 5.Patients with active systemic infections or those who have recently undergone corticosteroid or steroid therapy. 6.Patients with chronic pain or anxiety lasting more than 3 months, a history of long-term use of analgesics or sedatives, or a history of substance abuse. 7.Patients with preoperative cognitive impairment or hearing loss that prevents cooperation during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative Opioid Consumption; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality;Postoperative pain;Perioperative anxiety; | — |
Countries
China
Contacts
Public ContactYan Tao
Cancer Hospital Chinese Academy of Medical Sciences
Outcome results
None listed