Postoperative Local Spinal Analgesia
Conditions
Interventions
Control Group:analgesic
Experimental Group:Bupivacaine Liposome Injection
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
25 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Surgical type: Clearly identify the type of surgery that requires postoperative analgesia, and only select moderate to severe surgeries. 2. Age range: 18-65 years old. 3. Patient Pain Level: Ensure that the study subjects have clear symptoms of postoperative pain, such as a VAS (Visual Analog Scale) score of 4 or higher. 4. Consent to participate: Patients must understand the research content and sign an informed consent form. study carefully 5. General health condition: Patients need to be in a state of general health without serious cardiovascular, liver and kidney dysfunction and other diseases. 6. No allergy to local anesthetics: The patient has no history of allergy to local anesthetics. 7. There are no other factors that affect the effectiveness of local anesthetics, such as not using anticoagulant drugs, not having infections, etc 8. Research expectation: Patients should be willing and able to participate in the entire process of the study. 9. The ASA (American Society of Anesthesiologists) physical assessment level was at grade II, and there were no serious complications during the operation.
Exclusion criteria
Exclusion criteria: 1. Known to be allergic to local anesthetics or experimental drugs. 2. Diseases that affect the safety of local anesthesia, such as coagulation dysfunction. 3. Pain arises from reasons other than the surgical incision. 4. The presence of mental disorders makes it impossible to assess the degree of pain. 5. Severe liver and kidney dysfunction. 6. Simultaneously using other analgesic drugs that may affect the evaluation. 7. History of neuropathic pain or chronic pain. 8. Pregnant or lactating women. 9. Participate in other clinical trials that may affect the results of this trial. 10. Researchers believe that there are other situations that are not suitable for participating in this experiment. 11. Surgical complications: such as serious complications occurring during the surgical process. 12. Surgery using local anesthetics as a treatment or diagnostic method, such as spinal nerve block surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS pain scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| ODI scores;Incidence of nausea and vomiting; | — |
Countries
China
Contacts
Public ContactWei Bo
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed