Diastolic Heart Failure (Heart Failure with Preserved Ejection Fraction, HFpEF)
Conditions
Interventions
Observation group of patients with diastolic heart failure combined with/without sleep apnea:None
Patients with diastolic heart failure without sleep apnea:none
Sponsors
Fuwai Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2. Sign the informed consent form; 3. No concurrent heart failure with reduced ejection fraction, lung disease, neuromuscular disease, mental illness, etc. 4. Echocardiography is used to rule out hypertrophic cardiomyopathy, valvular heart disease, congenital heart disease, etc.
Exclusion criteria
Exclusion criteria: 1. Reduced ejection fraction, heart failure, lung disease, neuromuscular disease, mental illness, etc. 2. Echocardiography shows hypertrophic cardiomyopathy, valvular heart disease, congenital heart disease, etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic concordance and severity classification of Diastolic Heart Failure (Heart Failure with Preserved Ejection Fraction, HFpEF);Association strength between the presence of Sleep Apnea (SA) and the risk of developing Diastolic Heart Failure;Coronary Flow Reserve; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of left ventricular diastolic dysfunction;Left ventricular mass index and relative wall thickness;Estimated pulmonary artery systolic pressure;Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels;Coronary artery calcium score as observed on Coronary Computed Tomography Angiography (CCTA);Prevalence and control rate of comorbid cardiovascular risk factors;Incidence of a composite endpoint of Major Adverse Cardiovascular Events (MACE); | — |
Countries
China
Contacts
Public ContactDan Yang
Fuwai Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed