G Protein-Biased µ-Opioid Receptor Agonists in the Management of Pain Following Abdominal Surgery in the AICU

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600116254

Enrollment

Unknown

Registered

2026-01-07

Start date

2026-02-01

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute postoperative pain

Interventions

Oliceridine group:Oliceridine PCA

Sufentanil group:Sufentanil PCA

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age > 18 years; 2. ASA class II–III; 3. BMI 18.5–29.9; 4. Patients scheduled to undergo abdominal surgery under general anesthesia; 5. Patients scheduled for postoperative transfer to the AICU for continued care; 6. Receiving postoperative patient-controlled intravenous analgesia (PCA); 7. Provided written informed consent; 8. Postoperative NRS score >= 4.

Exclusion criteria

Exclusion criteria: 1. Pre-existing chronic pain or psychiatric disorders; 2. Inability to communicate due to cognitive impairment or language barriers prior to surgery; 3. Use of opioid medications within 3 days prior to surgery; 4. Long-term alcohol use; 5. Sleep apnea, or a STOP-Bang score >= 3, or acute/severe bronchial asthma; 6. Comorbid severe cardiovascular, respiratory, or autonomic nervous system diseases, and planned postoperative transfer to the general ICU; 7. Participation in other clinical trials involving drugs or medical devices within the past 3 months; 8. Pregnant or lactating women.

Design outcomes

Primary

Measure	Time frame
NRS score;	—

Secondary

Measure	Time frame
Time to First Flatus;Number of PCA Presses;Time to First PCA Press;Proportion of patients requiring rescue antiemetic medication within 24 hours postoperatively.;The incidence of adverse reactions within 24 hours postoperatively, including nausea, vomiting, dizziness, headache, constipation, pruritus, and respiratory depression.;Patient Recovery Quality Score, Postoperative Hospital Stay, and Satisfaction.;Rate of rescue analgesia and total rescue medication dosage within 24 hours after surgery.;	—

Measure

Time frame

Time to First Flatus;Number of PCA Presses;Time to First PCA Press;Proportion of patients requiring rescue antiemetic medication within 24 hours postoperatively.;The incidence of adverse reactions within 24 hours postoperatively, including nausea, vomiting, dizziness, headache, constipation, pruritus, and respiratory depression.;Patient Recovery Quality Score, Postoperative Hospital Stay, and Satisfaction.;Rate of rescue analgesia and total rescue medication dosage within 24 hours after surgery.;

—

Countries

China

Contacts

Public ContactYafeng Wang

Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology

wangyafengaaa@163.com+86 27 8572 6114

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026