Nasopharyngeal carcinoma(NPC)
Conditions
Interventions
Control group (Intervention Component):Control group patients received routine care. During chemoradiotherapy, one-on-one education was provided on basic knowledge of chemoradiotherapy, precautions be
Trial group (Intervention Component):Receive a symptom dynamic management protocol based on best available evidence-based practices, in addition to routine care.
Observation Group (Longitudinal Study Component):None
Sponsors
Sichuan Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Longitudinal Survey Component: 1. Age >=18 years; 2. Pathologically diagnosed with nasopharyngeal cancer, hypopharyngeal cancer, laryngeal cancer, or oropharyngeal cancer; 3. Able to understand the study content; 4. Receiving combined radiotherapy and chemotherapy; voluntarily participating in the study and signing the informed consent form. Intervention Study Component: 1. Age >=18 years; 2. Pathologically diagnosed with head and neck cancer (including nasopharyngeal, hypopharyngeal, laryngeal, and oropharyngeal cancers) and receiving concurrent chemoradiotherapy; 3. Able to understand the study content; 4. Voluntarily participating in the study and signing the informed consent form.
Exclusion criteria
Exclusion criteria: Intervention Study Component: 1. Patients with severe primary diseases of the liver, kidney, hematopoietic, or endocrine systems accompanied by severe organ failure; 2. Patients with other malignant tumors requiring treatment; 3. Patients with severe diseases involving other vital organs; 4. Patients currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient Symptom and Function Assessment: MDASI-HN Head and Neck Specific Module, EQ-5D-5L Health Status Scale;Symptom Maximum Burden: Patients in the head and neck cancer cohort undergo multiple symptom assessments with the scale at different time points.;Worst Physiological Status: The average score of the three MDASI functional items—"general activity," "walking," and "working"—represents the patient’s physiological status; the highest score recorded during the observation period in the cohort represents the worst physiological status.;Tumor Disease and Treatment Characteristics (chemoradiotherapy regimen, complications and their grading, timing and reasons for unplanned readmissions);Targeted/Immunotherapy: Regimen, complications and their grading, timing and reasons for unplanned readmissions;MD Anderson Symptom Inventory Head and Neck Module (Intervention Component);CSCRT-HN scale;Quality of Life Questionnaire;Unplanned Hospitalizations/Emergency Department Visits; | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic Characteristics (age, gender, ethnicity, education level, residence, employment status, social support, household income);Disease and Treatment-Related Information (diagnosis, pathological type, clinical stage, history of surgery, tracheostomy, number of hospitalizations, chemotherapy cycles, radiotherapy sessions, use of targeted and immunotherapy drugs);Symptom Severity Classification Criteria: Threshold Parameters for Mild/Moderate/Severe Levels of Core Symptoms in the Head and Neck Cancer Chemoradiotherapy Symptom Scale (Draft); | — |
Countries
China
Contacts
Public ContactLv Jianxia
Sichuan Cancer Hospital
Outcome results
None listed