Adult depression patients with suicidal ideation or behavior
Conditions
Interventions
Group of patients with SSRIs antidepressant:Oral SSRI antidepressants (such as sertraline, fluoxetine, etc.)
A group of patients were treated with Esketamine nasal spray combined with SSRIs antidepressant:Oral SSRI antidepressants (such as sertraline, fluoxetine, etc.) in combination with esketamine hydrochl
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Depressive disorder patients who meet the diagnostic criteria of ICD-10, aged 18–65 years old; 2. MADRS score total >= 20 points, with suicide item score >= 2 points; 3. Capable of understanding and complying with research requirements; 4. Capable of writing; normal audio-visual ability; 5. Capable of signing informed consent and willing to participate in research.
Exclusion criteria
Exclusion criteria: 1.Brain trauma, cerebrovascular disease, epilepsy, spasms, or intellectual disabilities; 2.Individuals with cataracts, other ophthalmic diseases, or hearing impairments; 3.Subjects with physical diseases diagnosed with ICD-10 have liver function aspartate aminotransferase>40 U/L, alanine aminotransferase>40 U/L, renal function estimated glomerular filtration rate440 ms, Female:>460 ms. 4.Based on medical history, it is determined that the patient meets the criteria for substance abuse or dependence in ICD-10 diagnosis. 5.Any other situation that researchers consider unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in MADRS total score (from baseline to Day 3 of enrollment);Change in BSS score (from baseline to Day 3 of enrollment);MADRS score reduction rate (%);BSS score reduction rate (%); | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical response rate: Proportion of patients with a >=50% reduction from baseline in MADRS total score;Clinical remission rate: Proportion of patients with MADRS total score <=10; | — |
Countries
China
Contacts
Public ContactJiang Wenhui
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed