Postoperative Delirium
Conditions
Interventions
Group Remimazolam:Total intravenous anesthesia with remimazolam
Sponsors
zhongda hospital southeast university
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with hip fracture and scheduled for elective repair surgery under general anesthesia; 2. Aged >= 65 years, regardless of gender; 3. ASA physical status I–III; 4. Frailty determined by preoperative screening (self-reported Edmonton Frailty Scale [REFS] score >= 6 points); 5. Patient or their authorized representative agrees to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with multiple injuries or fractures; 2.Patients with relative contraindications to general anesthesia (such as malignant hyperthermia); 3.Patients with visual, speech, or hearing impairments, or neuropsychiatric disorders (including those unable to cooperate with assessments or with impaired baseline MMSE scores); 4.Patients who have participated in other clinical studies within the past three months; 5.Patients deemed unsuitable for randomization by the anesthesiologist and surgeon for health reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of delirium within 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of delirium within 7 days after surgery(or prior to discharge);Burst suppression time and its proportion relative to the total surgery time;Preoperative and postoperative levels of the inflammatory cytokine and S-100ß protein;Emergence Delirium;Adverse events in the PACU;The Burden of Postoperative Delirium;Hypotension after anesthesia induction;Daily NRS score;Incidence of postoperative complications;Hemodynamic fluctuations;One-Month Postoperative Cognitive Follow-Up;Postoperative delirium subtypes, onset time, duration, frequency, and severity;Intraoperative awareness;Unplanned ICU admission; | — |
Countries
China
Contacts
Public ContactSun Jie
zhongda hospital southeast university
Outcome results
None listed